Isotopically Labeled Compounds
Medchemexpress LLC Pimozide-d4-1 | 2062-78-4 | 1 MG
Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM. Additionally, Pimozide inhibits STAT3 and STAT5.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Apalutamide-d4 | 1638885-65-0 | 99.9% | 481.46 | 1 MG
Apalutamide-d4 is a deuterium-labeled form of Apalutamide, which is a potent and competitive antagonist of the androgen receptor (AR) with an IC50 of 16 nM. This compound is intended for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Terazosin-d8 | 1006718-20-2 | 99.2% | 2.5 MG
Terazosin-d8 is a deuterium-labeled quinazoline derivative and a competitive, orally active α1-adrenoceptor antagonist. It functions by relaxing blood vessels and opening the bladder, making it suitable for potential applications in treating benign prostatic hyperplasia (BPH) and high blood pressure. Deuteration influences the pharmacokinetic and metabolic profiles of drugs.
- Competitive and orally active α1-adrenoceptor antagonist
- Relaxes blood vessels and opens the bladder
- Potential for benign prostatic hyperplasia (BPH) treatment
- Potential for high blood pressure treatment
- Can be used as a tracer or an internal standard
- Suitable for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Amlodipine-d4 | 1185246-14-3 | 98.5% | 5 MG
Amlodipine-d4 is a deuterium labeled Amlodipine. Amlodipine is an antianginal agent and an orally active dihydropyridine calcium channel blocker. It functions by blocking voltage-dependent L-type calcium channels, which inhibits the initial influx of calcium. Amlodipine can be utilized for the research of high blood pressure and cancer.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Cholesterol-d6-1 | 92543-08-3 | 99.82% | 392.69 | 1 MG
Cholesterol-d6-1 is deuterium labeled Cholesterol, a primary sterol in mammals that makes up 20-25% of the plasma membrane's structural component. It plays a significant role in determining the fluidity and permeability characteristics of the membrane, as well as the function of transporters and signaling proteins. It also acts as an endogenous estrogen-related receptor α (ERRα) agonist.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Pitavastatin-d4 sodium | 574705-92-3 | 99.7% | 1 MG
Pitavastatin-d4 sodium is a deuterium-labeled version of Pitavastatin sodium. Deuteration, the process of incorporating stable heavy isotopes of hydrogen (deuterium) into drug molecules, has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC Nortriptyline (hydrochloride) 894-71-3 10mM (in 1mL DMSO)
Nortriptyline hydrochloride (CAS 894-71-3) is a dibenzocycloheptene-derived tricyclic antidepressant that inhibits monoamine reuptake transporters It selectively blocks the norepinephrine transporter (NET) with a Ki of 3 4 nM and inhibits the serotonin transporter (SERT) with a Ki of 161 nM thereby increasing synaptic concentrations of these neurotransmitters in the central nervous system In vitro nortriptyline dose-dependently suppresses spontaneous migration and chemotaxis of human polymorphonuclear cells In vivo studies in rodents indicate partial blockade of noradrenaline depletion in nerve terminals at higher doses Nortriptyline is frequently employed in research on monoaminergic neurotransmission and antidepressant pharmacology
Medchemexpress LLC Memantine-d6 (hydrochloride) | 1189713-18-5 | 99.8% | 500 UG
Memantine-d6 (hydrochloride) is a deuterium labeled Memantine hydrochloride. It functions as a moderate affinity, uncompetitive NMDA receptor antagonist, inhibiting CYP2B6 and CYP2D6. This compound is intended for research use only, primarily as a tracer and internal standard for quantitative analysis. Deuteration, involving the incorporation of stable heavy isotopes into drug molecules, is utilized for quantitation during drug development and may influence pharmacokinetic and metabolic profiles.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes incorporated into drug molecules.
- Deuteration has the potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC DL-Tryptophan-d3 | 340257-61-6 | 99.3% | 207.24 | 25 MG
DL-Tryptophan-d3 is the deuterium labeled DL-Tryptophan, an endogenous metabolite for research use only. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Contains stable heavy isotopes of hydrogen, carbon, and other elements.
- Potential to affect pharmacokinetic and metabolic profiles of drugs.
Cambridge Isotope Laboratories ETHYL ACETATE (1-13C, 99%), 5 G, 3424-59-7
ETHYL ACETATE (1-13C, 99%), 5 G, 3424-59-7
Medchemexpress LLC 3-O-methyldopa-d3 hydrate | MFCD11983476 | 232.25 | C10H12D3NO5 | 5 MG
3-O-Methyldopa-d3 hydrate is the deuterium-labeled form of 3-O-methyldopa supplied as a white to off-white solid hydrate. It is designed for use as an internal standard or tracer in quantitative analyses and for research on dopamine metabolism and related neurological disorders.
- Deuterium-labeled internal standard for LC-MS, GC-MS, and NMR.
- Suitable for quantitative tracer and assay development.
- Solid hydrate form with stable isotopic labeling.
- Useful in studies of dopamine metabolism and neurological disease models.
- Supplied in small research-scale quantities for analytical applications.
Medchemexpress LLC Fingolimod-d4 hydrochloride | 1346604-90-7 | 99.0% | 347.96 g/mol | C19H30D4ClNO2 | 5 MG
Fingolimod-d4 hydrochloride is the deuterium-labeled hydrochloride salt of fingolimod provided for research use. It is supplied as a solid with high chemical and isotopic purity, intended as an internal standard or tracer for analytical, pharmacokinetic, and bioanalytical studies. The compound is soluble in DMSO and is stored sealed away from moisture; solvent storage conditions apply.
Cambridge Isotope Laboratories L-LEUCINE-N-T-BOC:H2O (2-13C, 99%), 0.25 G
L-LEUCINE-N-T-BOC:H2O (2-13C, 99%), 0.25 G
Medchemexpress LLC Ethyl octanoate-d15 | 1219798-38-5 | 98.5% | 187.36 | C10H5D15O2 | 50 MG
Ethyl octanoate-d15 is the deuterium-labeled analogue of ethyl octanoate provided for use as a stable-isotope tracer and internal standard in analytical chemistry. It is intended for mass spectrometry, tracer studies, and quantitative analysis where isotopic distinction from the native compound is required.
- Deuterium-labeled (d15) ethyl octanoate for isotopic tracing.
- High chemical purity (98.5%) suitable for analytical use.
- Suitable as an internal standard for mass spectrometry and quantitative analysis.
- Colorless to light yellow liquid with density 0.867 g/cm³.
- Available in small, research-scale quantities (mg-range).
- Certificate of analysis and safety data sheet available.